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Glycolysis! (Mr. W's Music Video)

admin by admin
July 3, 2020
in Game
32
Glycolysis! (Mr. W's Music Video)



Are you taking AP Bio or IB Bio? Or a college intro Bio class?
If you’re a fan of learning with interactive tutorials and science music videos like these,
you can get more songs and tutorials at
80% of my students get a 4 or 5 on the AP Bio test using my tutorials and songs!

Between now and the AP exam (5/18/20) Live AP Bio review sessions every Tuesday and Thursday at 2pm PST: go to

Students: Get great AP Bio prep materials (or IB Bio prep or help with your college Intro to Bio course. )
We’ve got tutorials, Flashcards, AP Bio FRQs, and more songs like The Glycolysis Rap.
Learn more and sign up for a free trial at:

AP or IB Bio Teachers: Help your students learn and prep for the AP Bio or IB Bio tests.
We’ve got AP Bio Prep tutorials, Flashcards, FRQs, and more songs like The Glycolysis Rap.
Learn more and sign up to try it out at:

College Professors/Instructors: Help your students master the most complex topics in biology, with interactive tutorials about DNA replication, photosynthesis, immunity, cellular respiration, and so much more. To get your students ready for midterms and finals we’ve got Flashcards, FRQs, and more songs like The Glycolysis Rap.
Learn more and sign up to try it out at:

Buy the Biomania AP Bio Test Prep App:

Buy my songs at or on Amazon at

Follow mr.w_science on instagram:

SUMMARY: Glycolysis is the first step in cellular respiration. This rap lecture teaches all you need to know about glycolysis at the AP Biology or Freshman Biology level.

LYRICS
Glycolysis is a series of reactions,
Enzymatic actions, energy transactions,
Takes glucose, a molecule so sugary,
Breaks it down for NADH and ATP

It’s an anaerobic cytoplasmic pathway that amazes
Organized easily into three phases,
Investment, cleavage, and energy harvest,
Tell me later which one you like best.

Investment: activation energy’s supplied,
Cleavage: our six carbon sugar divides
Harvest: we get our energy yield,
So beautiful, so intricate keep your eyes peeled

CHORUS
Glycolysis!
Come on sugar, come on sugar, for the breakdown. For the breakdown.

Investment’s like striking a match,
That energy you put in makes the fire catch
For glycolysis investments two ATPs,
Which act as activation energy

Enzymes take phosphate from ATPs
Jam ’em on a glucose rearranging it to fructose,
Leaving Fructose 1- 6 bisphosphate on the table,
With two phosphates, it’s highly unstable!

Moving us to the second phase
The cleaving of Fructose bisphosphate
Cause glycolysis means splitting sugar, you can see
cleavage yields two molecules with carbons three

One is glyceraldehyde 3 phosphate G3P
It continues on our pathway broken down for energy
But the second one an enzyme will immediately,
Convert into a second G3P

CHORUS

Phase 3: G3P gets rearranged and oxidized,
By an enzymatic assembly line,
That harvest energy from each G3P
One NADH and 2 ATPs

Double this yield per G3P
To two NADH and 4 ATPs
That’s the gross yield for every glucose in
A generous accounting of glycolysis’s win

But 2ATPs were invested in phase 1
So you net just two you can use to jump or run,
Put two in, get four out, your net gain is two,
Two ATPs that you can use.

If that doesn’t seem like very much, it’s cause it ain’t,
There’s tons of energy left in pyruvate,
The two three carbon molecules we’re left with at the end.
And what happens to pyruvate is gonna depend,

On the metabolic pathway where pyruvate gets sent,
If its anaerobic it’ll be fermented
But in aerobic cells pyruvate’s termination
Will be the Krebs cycle and total oxidation!

CHORUS

Review: glycolysis starts with investment
of two ATPs to the glucose that we started with,
The product is cleaved into two G3Ps
From which the cell harvests NADH and ATPs.

This anaerobic pathway is respiration’s first phase,
It’s billions of year’s old evolved in ancient days
before O2 accumulated in the seas, before
eukaryotic cells like ours arrived on the scene

It’s everywhere, ubiquitous, in every organism,
Bacteria, sequoia tree, no matter your metabolism,
Happens in the cytoplasm doesn’t need no organelles.
You wanna find glycolysis? Look in any cell!

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Comments 32

  1. sciencemusicvideos says:
    1 year ago

    Between now and the AP exam (5/18/20) Live AP Bio review sessions every Tuesday and Thursday at 2pm PST: go to https://sciencemusicvideos.com/mr-w-live/

    Reply
  2. Jordan Yanda says:
    1 year ago

    Thank you, this video summarizes the topic, I will sit for my bio-chem exam next week monday

    Reply
  3. Arushi Kumar says:
    1 year ago

    wish if the toughest tasks were like this….such 'melodious' studies make life a cakewalk😍😘

    Reply
  4. Shigi says:
    1 year ago

    bars for days!!! That was awesome. Such a fun teacher!!

    Reply
  5. Juliet Capulet says:
    1 year ago

    MCAT in a week. LES GO

    Reply
  6. CRA1NEY1 says:
    1 year ago

    top 10 rappers eminem was to affraid to diss

    Reply
  7. Henry Singleton says:
    1 year ago

    He do be dropping bars doe!

    Reply
  8. Vanessa Rodriguez says:
    1 year ago

    This was amazing

    Reply
  9. helicas says:
    1 year ago

    even after having taken AP Bio a year ago already, I still come back to your music videos because they are just great!

    Reply
  10. Jillian Skerchak says:
    1 year ago

    I first heard this rap 5 years ago in my AP biology class. I am now listening to it while I study for MCAT. My this video has aged well!

    Reply
  11. Christy Daugherty says:
    1 year ago

    I just want to thank this man. Not only was that amazingly catchy and hilarious, it was super informative and gave me the refresher on glycolysis that I needed. Thank you thank you thank you Mr. W lol!

    Reply
  12. lawrence mersino says:
    1 year ago

    Yesssssss. Please do one for the electron transport chain!

    Reply
  13. Lee Chishan Gañan Jaramillo says:
    1 year ago

    Me gustaria con subtitulos en español

    Reply
  14. Juan Torres says:
    1 year ago

    En español:( i love u

    Reply
  15. lost gaze says:
    1 year ago

    I learn nothing and just bob my head with the rhythm! Its really cool:) 👍

    Reply
  16. Anna G. De Leon-Oca says:
    1 year ago

    i’m sharing this with a bunch of my friends because you helped me get my degree 🥺😂🤍

    Reply
  17. Guy Incognito says:
    1 year ago

    The breakdown hits harder than my stepdad

    Reply
  18. Simran Lazrado says:
    1 year ago

    drop the mix tape glenn

    Reply
  19. jay dope says:
    1 year ago

    This quarantine got me watching everything in this app

    Reply
  20. Mansi Koerala says:
    1 year ago

    Shit* trying not to laugh
    my parents won't believe that I was actually studying 😂😂😂😂

    Reply
  21. jyoti bansile says:
    1 year ago

    Amazing sir Thanks a lot

    Reply
  22. Bon Holliday says:
    1 year ago

    🔥🔥🔥🔥🔥

    Reply
  23. Christine Vakas says:
    1 year ago

    Thank you this will be catchy enough for me to remember the material, and actually enjoy learning.

    Reply
  24. SoKaar’s Legion says:
    1 year ago

    This guy is my actual teacher at Berkeley High School. Feels good to be taught by a celebrity.

    Reply
  25. Neil Christian Bolotaolo says:
    1 year ago

    I love the music video Sir! Especially the chorus, it really made a great impression! I simply love it!! <3

    Reply
  26. Katherine Sanchez says:
    1 year ago

    My friend says she loves your video

    Reply
  27. Joseph Schommer says:
    1 year ago

    Im in love with mr w

    Reply
  28. Melissa Garza Martínez says:
    1 year ago

    I remember when I first heard this song. Our biology teacher showed us this video and we all learnt it for our biology quiz on glycolysis and cellular respiration. That was back in 2013 when I was in 7th grade. Yet here I am, 7 years later and I still know every lyric to the song and have used it endless times during high school and now that I am studying medicine.

    May my biology teacher rest in peace, and thank you Mr.W for this amazing tutorial which has helped me and my classmates lots.

    Best. Song. Ever. For. Studying. Glycolysis.

    Reply
  29. Anony Nomous says:
    1 year ago

    Highly cringe but reaaaaaally helps me in remembering the processes 😂 I am throughly enjoying your vids!

    Reply
  30. cengiz says:
    1 year ago

    The chorus is generally unreal I sing it all the time

    Reply
  31. Mikus Kacz says:
    1 year ago

    0:40

    Reply
  32. Mosa Dondolo says:
    1 year ago

    CAN YOU PLEASE BE MY LECTURER?

    Reply

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